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Article

Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions.

The Journal of experimental medicine - 5 Apr 2004

Zeng Xianmin, Negrete George A, Kasmer Cynthia, Yang William W, Gearhart Patricia J

Abstract excerpt

Activation-induced cytosine deaminase preferentially deaminates C in DNA on the nontranscribed strand in vitro, which theoretically should produce a large increase in mutations of C during hypermutation of immunoglobulin genes. However, a bias for C mutations has not been observed among the mutat...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Directed DNA Polymerase

Share to Immunoglobulin mu-Chains

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Source

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Identifiers

PMID: 15051760
DOI: 10.1084/jem.20032022
PMCID: PMC2211872

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15051760-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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