Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA Polymerase η Is Involved in Hypermutation Occurring during Immunoglobulin Class Switch Recombination

19 Jan 2004

Abstract excerpt

Base substitutions, deletions, and duplications are observed at the immunoglobulin locus in DNA sequences involved in class switch recombination (CSR). These mutations are dependent upon activation-induced cytidine deaminase (AID) and present all the characteristics of the ones observed during V gene somatic hypermutation, implying that they could be generated by the same mutational complex. It has been proposed,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to DNA Repair Mechanisms
Share to Polyomavirus and related diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14734526
DOI: 10.1084/jem.20031831

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA Polymerase η Is Involved in Hypermutation Occurring during Immunoglobulin Class Switch RecombinationPMID 14734526Read ↗

Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions.Semantic proximity Read ↗

Large deletions in immunoglobulin genes are associated with a sustained absence of DNA Polymerase η.Semantic proximity Read ↗

Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.Semantic proximity Read ↗

Somatic mutation patterns at Ig and Non-Ig Loci.Semantic proximity Read ↗

A backup role of DNA polymerase kappa in Ig gene hypermutation only takes place in the complete absence of DNA polymerase eta.Semantic proximity Read ↗

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes.Semantic proximity Read ↗

Contribution of DNA polymerase η to immunoglobulin gene hypermutation in the mouseSemantic proximity Read ↗

Human DNA polymerase-eta, an A-T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase.Semantic proximity Read ↗

Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation.Semantic proximity Read ↗

Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates.Semantic proximity Read ↗

DNA polymerase η is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouseSemantic proximity Read ↗

Reevaluation of the role of DNA polymerase θ in somatic hypermutation of immunoglobulin genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.