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Article

The role of polymerase eta in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variant.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2002

Yavuz Sule, Yavuz Akif S, Kraemer Kenneth H, Lipsky Peter E

Abstract excerpt

To determine the possible role of polymerase eta (pol eta) in somatic hypermutation of B cells, a mutational analysis of 24 nonproductive rearrangements from a patient with xeroderma pigmentosum variant with a defect in pol eta was conducted. Although the mutational frequency of A and T bases decreased in WA (A/T, A) motifs, regardless of their RGYW (purine, G; pyrimidine, A/T) context, the overall mutational...

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Share to Base Pair Mismatch
Share to DNA-Directed DNA Polymerase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin Variable Region

Share to Repetitive Sequences, Nucleic Acid

Share to Somatic Hypermutation, Immunoglobulin

Share to Xeroderma Pigmentosum

Source

Identifiers

PMID: 12244178
DOI: 10.4049/jimmunol.169.7.3825

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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