Article
The Fanconi anemia core complex is dispensable during somatic hypermutation and class switch recombination.
PloS one - 29 Dec 2010
Krijger Peter H L, Wit Niek, van den Berk Paul C M, Jacobs Heinz
Abstract excerpt
To generate high affinity antibodies during an immune response, B cells undergo somatic hypermutation (SHM) of their immunoglobulin genes. Error-prone translesion synthesis (TLS) DNA polymerases have been reported to be responsible for all mutations at template A/T and at least a fraction of G/C transversions. In contrast to A/T mutations which depend on PCNA ubiquitination, it remains unclear how G/C...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.