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Article

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes.

Nature immunology - 1 Jun 2001

Zeng X, Winter D B, Kasmer C, Kraemer K H, Lehmann A R, Gearhart P J

Abstract excerpt

To determine whether DNA polymerase eta plays a role in the hypermutation of immunoglobulin variable genes, we examined the frequency and pattern of substitutions in variable VH6 genes from the peripheral blood lymphocytes of three patients with xeroderma pigmentosum variant disease, whose polyme...

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PMID: 11376341
DOI: 10.1038/88740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11376341-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes.PMID 11376341Read ↗

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