Article
DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes.
Proceedings of the National Academy of Sciences of the United States of America - 27 Sept 2005
Masuda Keiji, Ouchida Rika, Takeuchi Arata, Saito Takashi, Koseki Haruhiko, Kawamura Kiyoko, Tagawa Masatoshi, Tokuhisa Takeshi, Azuma Takachika, O-Wang Jiyang
Abstract excerpt
Somatic hypermutation of Ig variable region genes is initiated by activation-induced cytidine deaminase; however, the activity of multiple DNA polymerases is required to ultimately introduce mutations. DNA polymerase eta (Poleta) has been implicated in mutations at A/T, but polymerases involved in C/G mutations have not been identified. We have generated mutant mice expressing DNA polymerase (Pol) specifically...
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