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Article

Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.

Nature - 31 Oct 2002

Faili Ahmad, Aoufouchi Said, Flatter Eric, Guéranger Quentin, Reynaud Claude-Agnès, Weill Jean-Claude

Abstract excerpt

Somatic hypermutation of immunoglobulin genes is a unique, targeted, adaptive process. While B cells are engaged in germinal centres in T-dependent responses, single base substitutions are introduced in the expressed Vh/Vl genes to allow the selection of mutants with a higher affinity for the immunizing antigen. Almost every possible DNA transaction has been proposed to explain this process, but each of these...

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PMID: 12410315
DOI: 10.1038/nature01117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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