Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.

doi:10.1038/nature01117

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Article

Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.

Nature - 31 Oct 2002

Faili Ahmad, Aoufouchi Said, Flatter Eric, Guéranger Quentin, Reynaud Claude-Agnès, Weill Jean-Claude

Abstract excerpt

Somatic hypermutation of immunoglobulin genes is a unique, targeted, adaptive process. While B cells are engaged in germinal centres in T-dependent responses, single base substitutions are introduced in the expressed Vh/Vl genes to allow the selection of mutants with a higher affinity for the immunizing antigen. Almost every possible DNA transaction has been proposed to explain this process, but each of these...

Topics

Antibody Affinity
B-Lymphocytes
Blotting, Western
Burkitt Lymphoma
Cytidine Deaminase
DNA-Directed DNA Polymerase
Gene Deletion
Genes, Immunoglobulin
Humans
Immunoglobulins
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

RNA, Messenger

Somatic Hypermutation, Immunoglobulin

Transfection

Tumor Cells, Cultured

DNA Polymerase iota

AICDA (Activation-Induced Cytidine Deaminase)

Source

Open in PubMed

Identifiers

PMID: 12410315
DOI: 10.1038/nature01117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12410315-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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