Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition.

The EMBO journal - 7 Apr 2004

Tanabe Tsuyoshi, Chamaillard Mathias, Ogura Yasunori, Zhu Li, Qiu Su, Masumoto Junya, Ghosh Partho, Moran Anthony, Predergast Martina M, Tromp Gerard, Williams Charlene J, Inohara Naohiro, Núñez Gabriel

Abstract excerpt

Multiple genetic variants of CARD15/NOD2 have been associated with susceptibility to Crohn's disease and Blau syndrome. NOD2 recognizes muramyl dipeptide (MDP) derived from bacterial peptidoglycan (PGN), but the molecular basis of recognition remains elusive. We performed systematic mutational an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteria
Share to Cell Line
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Models, Molecular

Share to Nod2 Signaling Adaptor Protein

Share to Point Mutation

Share to Protein Structure, Tertiary

Source

Open in PubMed Open full text

Identifiers

PMID: 15044951
DOI: 10.1038/sj.emboj.7600175
PMCID: PMC391079

Genes

NOD2
NOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15044951-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition.PMID 15044951Read ↗

Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease.Semantic proximity Read ↗

Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) DetectionSemantic proximity Read ↗

Towards an understanding of the role of NOD2/CARD15 in the pathogenesis of Crohn's disease.Semantic proximity Read ↗

Functional consequences of NOD2 (CARD15) mutations.Semantic proximity Read ↗

NOD2, an intracellular innate immune sensor involved in host defense and Crohn's disease.Semantic proximity Read ↗

Insights into the molecular basis of the NOD2 signalling pathwaySemantic proximity Read ↗

The molecular basis of NOD2 susceptibility mutations in Crohn's disease.Semantic proximity Read ↗

NOD2 mutations affect muramyl dipeptide stimulation of human B lymphocytes and interact with other IBD-associated genes.Semantic proximity Read ↗

Resolving the field: a role for Nod2 in T cells.Semantic proximity Read ↗

Lessons from Nod2 studies: towards a link between Crohn's disease and bacterial sensing.Semantic proximity Read ↗

Innate Immune Sensing of Microbes by Nod ProteinsSemantic proximity Read ↗

Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.