Article
Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease.
The Journal of biological chemistry - 21 Feb 2003
Inohara Naohiro, Ogura Yasunori, Fontalba Ana, Gutierrez Olga, Pons Fernando, Crespo Javier, Fukase Koichi, Inamura Seiichi, Kusumoto Shoichi, Hashimoto Masahito, Foster Simon J, Moran Anthony P, Fernandez-Luna Jose L, Nuñez Gabriel
Abstract excerpt
NOD2, a protein associated with susceptibility to Crohn's disease, confers responsiveness to bacterial preparations of lipopolysaccharide and peptidoglycan, but the precise moiety recognized remains elusive. Biochemical and functional analyses identified muramyl dipeptide (MurNAc-L-Ala-D-isoGln) derived from peptidoglycan as the essential structure in bacteria recognized by NOD2. Replacement of L-Ala for D-Ala or...
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