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Article

Skp2 gene copy number aberrations are common in non-small cell lung carcinoma, and its overexpression in tumors with ras mutation is a poor prognostic marker.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2004

Zhu Chang Qi, Blackhall Fiona H, Pintilie Melania, Iyengar Pratibha, Liu Ni, Ho James, Chomiak Taylor, Lau Davina, Winton Timothy, Shepherd Frances A, Tsao Ming-Sound

Abstract excerpt

PURPOSE: Skp2 plays a critical role in cell cycle progression, especially at the G(1)-S transition, putatively through its control of several cell cycle regulator proteins. The Skp2 gene is located on a region of chromosome 5p that is commonly overrepresented in lung cancer. The present study aim...

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Share to Carcinoma, Non-Small-Cell Lung
Share to Chromosome Aberrations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Genes, ras

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Share to S-Phase Kinase-Associated Proteins

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Source

Identifiers

PMID: 15041716
DOI: 10.1158/1078-0432.ccr-03-0470

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15041716-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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