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Article

High Skp2 Expression Characterizes High-Risk Neuroblastomas Independent of MYCN Status

25 Jul 2007

Abstract excerpt

PURPOSE: Amplified MYCN oncogene defines a subgroup of neuroblastomas with poor outcome. However, a substantial number of MYCN single-copy neuroblastomas exhibits an aggressive phenotype similar to that of MYCN-amplified neuroblastomas even in the absence of high MYCN mRNA and/or protein levels. EXPERIMENTAL DESIGN: To identify shared molecular mechanisms that mediate the aggressive phenotype in MYCN-amplified...

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PMID: 17652624
DOI: 10.1158/1078-0432.ccr-06-2818

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High Skp2 Expression Characterizes High-Risk Neuroblastomas Independent of MYCN StatusPMID 17652624Read ↗

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