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Article

Abnormal expression of the pre-mRNA splicing regulators SRSF1, SRSF2, SRPK1 and SRPK2 in non small cell lung carcinoma.

PloS one - 1 Jan 2012

Gout Stephanie, Brambilla Elisabeth, Boudria Asma, Drissi Romain, Lantuejoul Sylvie, Gazzeri Sylvie, Eymin Beatrice

Abstract excerpt

Splicing abnormalities frequently occur in cancer. A key role as splice site choice regulator is played by the members of the SR (Ser/Arg-rich) family of proteins. We recently demonstrated that SRSF2 is involved in cisplatin-mediated apoptosis of human lung carcinoma cell lines. In this study, by using immunohistochemistry, we demonstrate that the SR proteins SRSF1 and SRSF2 are overexpressed in 63% and 65% of...

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Source

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Identifiers

PMID: 23071587
DOI: 10.1371/journal.pone.0046539
PMCID: PMC3468597

Genes

SRSF2
SRSF1
SRPK2
SRPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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