Article
Clinical potential of SKP2 as diagnostic marker and therapeutic target in small cell lung cancer.
Respiratory investigation - 1 Sept 2024
Matsumoto Naohisa, Tajima Ken, Takahashi Fumiyuki, Mitsuishi Yoichiro, Wirawan Aditya, Hidayat Moulid, Winardi Wira, Wibowo Adityo, Hayakawa Daisuke, Izumi Kenta, Kanamori Koichiro, Miyashita Yosuke, Handa Takafumi, Asao Tetsuhiko, Ko Ryo, Shukuya Takehito, Shimada Naoko, Takamochi Kazuya, Hayashi Takuo, Suzuki Kenji, Takahashi Kazuhisa
Abstract excerpt
BACKGROUND: Small cell lung cancer (SCLC) is the most aggressive type of lung cancer. The overall survival has not improved significantly over the last decades because no major therapeutic breakthroughs have been achieved for over 15 years. METHODS: We analyzed a genome-wide loss-of-function screening database to identify vulnerabilities in SCLC for the development of urgently needed novel therapies. RESULTS: We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.