Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SKP2 is a direct transcriptional target of MYCN and a potential therapeutic target in neuroblastoma.

Cancer letters - 10 Jul 2015

Evans Laura, Chen Lindi, Milazzo Giorgio, Gherardi Samuele, Perini Giovanni, Willmore Elaine, Newell David R, Tweddle Deborah A

Abstract excerpt

SKP2 is the substrate recognition subunit of the ubiquitin ligase complex which targets p27(KIP1) for degradation. Induced at the G1/S transit of the cell cycle, SKP2 is frequently overexpressed in human cancers and contributes to malignancy. We previously identified SKP2 as a possible MYCN target gene and hence hypothesise that SKP2 is a potential therapeutic target in MYCN amplified disease. A positive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to G1 Phase Cell Cycle Checkpoints

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Reporter

Share to N-Myc Proto-Oncogene Protein

Share to Neuroblastoma

Share to Oncogene Proteins

Share to RNA Interference

Share to S-Phase Kinase-Associated Proteins

Source

Identifiers

PMID: 25843293
DOI: 10.1016/j.canlet.2015.03.044

Genes

MYCN
SKP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SKP2 is a direct transcriptional target of MYCN and a potential therapeutic target in neuroblastoma.PMID 25843293Read ↗

High Skp2 Expression Characterizes High-Risk Neuroblastomas Independent of MYCN StatusSemantic proximity Read ↗

SKP2 Oncogene Is a Direct MYC Target Gene and MYC Down-regulates p27KIP1 through SKP2 in Human Leukemia CellsSemantic proximity Read ↗

p53, SKP2, and DKK3 as MYCN Target Genes and Their Potential Therapeutic SignificanceSemantic proximity Read ↗

Dissection of the oncogenic MYCN transcriptional network reveals a large set of clinically relevant cell cycle genes as drivers of neuroblastoma tumorigenesisSemantic proximity Read ↗

The p53 regulatory gene <i>MDM2</i> is a direct transcriptional target of MYCN in neuroblastomaSemantic proximity Read ↗

Skp2: A critical molecule for ubiquitination and its role in cancerSemantic proximity Read ↗

SKping cell cycle regulation: role of ubiquitin ligase SKP2 in hematological malignanciesSemantic proximity Read ↗

Skp2 regulates Myc protein stability and activity.Semantic proximity Read ↗

Regulation of Skp2 Expression and Activity and Its Role in Cancer ProgressionSemantic proximity Read ↗

Functions of Shp2 in cancer.Semantic proximity Read ↗

FOXR2 Stabilizes MYCN Protein and Identifies Non–MYCN-Amplified Neuroblastoma Patients With Unfavorable OutcomeSemantic proximity Read ↗

MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.