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Article

Role of the F-box protein Skp2 in lymphomagenesis

20 Feb 2001

Abstract excerpt

The F-box protein Skp2 (S-phase kinase-associated protein 2) positively regulates the G(1)-S transition by controlling the stability of several G(1) regulators, such as the cell cycle inhibitor p27. We show here that Skp2 expression correlates directly with grade of malignancy and inversely with p27 levels in human lymphomas. To directly evaluate the potential of Skp2 to deregulate growth in vivo, we generated...

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PMID: 11226270
DOI: 10.1073/pnas.041475098

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