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Article

A Leu----His substitution at residue 93 in human corticosteroid binding globulin results in reduced affinity for cortisol.

The Journal of steroid biochemistry and molecular biology - 1 Aug 1992

Smith C L, Power S G, Hammond G L

Abstract excerpt

A steroid binding capacity assay and a radioimmunoassay were both used to measure corticosteroid binding globulin (CBG) in serum samples from 22 patients with sepsis. An approximately 50% discordancy between the two values in one patient suggested the presence of a CBG variant with reduced affini...

Topics

Aged
Animals
Base Sequence
CHO Cells
Cloning, Molecular
Cricetinae
DNA
Female
Histidine
Humans
Hydrocortisone
Leucine
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polymerase Chain Reaction

Transcortin

Source

Identifiers

PMID: 1504007
DOI: 10.1016/0960-0760(92)90107-t

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1504007-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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