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Article

A Leu----His substitution at residue 93 in human corticosteroid binding globulin results in reduced affinity for cortisol.

The Journal of steroid biochemistry and molecular biology - 1 Aug 1992

Smith C L, Power S G, Hammond G L

Abstract excerpt

A steroid binding capacity assay and a radioimmunoassay were both used to measure corticosteroid binding globulin (CBG) in serum samples from 22 patients with sepsis. An approximately 50% discordancy between the two values in one patient suggested the presence of a CBG variant with reduced affinity for cortisol, and this was confirmed by Scatchard analysis. We therefore used the polymerase chain reaction to...

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PMID: 1504007
DOI: 10.1016/0960-0760(92)90107-t

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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