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Article

A Novel Human Glucocorticoid Receptor Variant, G459V, is Hyperactive in Response to Steroids.

Shock (Augusta, Ga.) - 1 Aug 2021

Grigsby Melissa J, Green Tajia L, Lim Debora, Cho Kiho, Greenhalgh David G

Abstract excerpt

ABSTRACT: A potential cause of the variable response to injury and sepsis is the variability of a patient's human glucocorticoid receptor (hGR) profile. To identify hGR variants, blood samples were collected on admission and biweekly thereafter from hospitalized patients who sustained at least a 20% total body surface area burn injury. A hyperactive G1376T single-nucleotide polymorphism (SNP) isoform was...

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Identifiers

PMID: 34276041
DOI: 10.1097/SHK.0000000000001729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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