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Contrasting incidence of ras mutations in rat mammary and mouse skin tumors induced by anti-benzo[c]phenanthrene-3,4-diol-1,2-epoxide.

Carcinogenesis - 1 Oct 1994

Ronai Z A, Gradia S, el-Bayoumy K, Amin S, Hecht S S

Abstract excerpt

Racemic anti-benzo[c]phenanthrene-3,4-diol-1,2-epoxide (anti-B[c]PhDE) is a powerful rat mammary carcinogen and is one of the most potent diol-epoxide tumorigens in mouse skin. Activation of ras genes has been proposed to be involved in tumorigenesis by this and related polynuclear aromatic hydrocarbon metabolites. Therefore, we analyzed rat mammary tumors and mouse skin tumors induced by anti-B[c]PhDE for...

Topics

Adenocarcinoma
Animals
Base Sequence
Benz(a)Anthracenes
Carcinogens
Codon
Female
Genes, ras
Mammary Neoplasms, Experimental
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Rats

Skin Neoplasms

Source

Identifiers

PMID: 7955041
DOI: 10.1093/carcin/15.10.2113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7955041-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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