Article
Dose-related changes in the profile of ras mutations in chemically induced CD-1 mouse liver tumors.
Carcinogenesis - 1 May 1995
Manam S, Shinder G A, Joslyn D J, Kraynak A R, Hammermeister C L, Leander K R, Ledwith B J, Prahalada S, van Zwieten M J, Nichols W W
Abstract excerpt
We investigated the role of dosing regimen on ras mutations in chemically induced CD-1 mouse liver tumors. The spectra of ras gene mutations in liver tumors that were induced by 15 daily i.p. injections of 7,12-dimethylbenz[a]anthracene (DMBA), 4-aminoazobenzene (AAB), N-hydroxy-2-acetylaminofluo...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Alleles
- Animals
- Carcinogens
- Codon
- DNA, Neoplasm
- Diethylnitrosamine
- Dose-Response Relationship, Drug
- Genes, ras
- Hydroxyacetylaminofluorene
- Liver Neoplasms
- Male
- Mice
- Mice, Inbred Strains
- Point Mutation
- Polymerase Chain Reaction
- p-Aminoazobenzene