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Article

Thymic stromal lymphopoietin drives the development of IL-13 + Th2 cells

16 Jan 2018

Abstract excerpt

Significance T helper 2 (Th2) cells are defined by their ability to produce the hallmark cytokine IL-4. However, to mediate allergic inflammation in tissues, Th2 cells must secrete additional cytokines including IL-13 and IL-5. We used IL-4 and IL-13 dual-reporter mice to show that naive CD4 + T cells cultured in the presence of IL-4 and thymic stromal lymphopoietin (TSLP) generate a population of IL-4 neg IL-13...

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PMID: 29339496
DOI: 10.1073/pnas.1714348115

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