Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myeloid-IL4Rα is an indispensable link in IL-33-ILCs-IL-13-IL4Rα axis of eosinophil recruitment in murine lungs.

Scientific reports - 29 Jul 2021

Patial Sonika, Lewis Brandon W, Vo Thao, Choudhary Ishita, Paudel Kshitiz, Mao Yun, Singamsetty Dhruthi, Brombacher Frank, Saini Yogesh

Abstract excerpt

Increased eosinophil recruitment is a hallmark feature of eosinophilic disorders. Here, we delineated the key molecular and cellular players involved in physiological eosinophilic recruitment during normal postnatal lung development in mice. Physiological eosinophilic recruitment was consistently present in 7-, 10-, and 15-day-old neonatal mice, but not in 42-day-old mice. This feature was completely abolished in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bronchoalveolar Lavage Fluid
Share to Eosinophils

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunity, Innate

Share to Interleukin-13

Share to Interleukin-33

Share to Lymphocytes

Share to Myeloid Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 34326406
DOI: 10.1038/s41598-021-94843-9
PMCID: PMC8322172

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myeloid-IL4Rα is an indispensable link in IL-33-ILCs-IL-13-IL4Rα axis of eosinophil recruitment in murine lungs.PMID 34326406Read ↗

Elevated IL-33 expression is associated with pediatric eosinophilic esophagitis, and exogenous IL-33 promotes eosinophilic esophagitis development in mice.Semantic proximity Read ↗

IL-13 Receptor α1 Differentially Regulates Aeroallergen-Induced Lung ResponsesSemantic proximity Read ↗

Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production.Semantic proximity Read ↗

Differential activation of airway eosinophils induces IL-13-mediated allergic Th2 pulmonary responses in mice.Semantic proximity Read ↗

The transcription factor GATA3 is critical for the development of all IL-7Rα-expressing innate lymphoid cells.Semantic proximity Read ↗

Essential and instructive roles of GATA factors in eosinophil development.Semantic proximity Read ↗

IL-13 Induces Esophageal Remodeling and Gene Expression by an Eosinophil-Independent, IL-13Rα2–Inhibited PathwaySemantic proximity Read ↗

Distinct roles for thymic stromal lymphopoietin (TSLP) and IL-33 in experimental eosinophilic esophagitisSemantic proximity Read ↗

Differential roles for IL-4Rα and IL-13Rα1 in immune cell infiltration and epithelial remodeling in experimental eosinophilic gastritisSemantic proximity Read ↗

Transcription Factor Repertoire of Homeostatic EosinophilopoiesisSemantic proximity Read ↗

Re-defining the unique roles for eosinophils in allergic respiratory inflammation.Semantic proximity Read ↗

Enhanced Interleukin (IL)-13 Responses in Mice Lacking IL-13 Receptor α 2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.