Article
Requirement for IL-13 independently of IL-4 in experimental asthma.
Science (New York, N.Y.) - 18 Dec 1998
Grünig G, Warnock M, Wakil A E, Venkayya R, Brombacher F, Rennick D M, Sheppard D, Mohrs M, Donaldson D D, Locksley R M, Corry D B
Abstract excerpt
The pathogenesis of asthma reflects, in part, the activity of T cell cytokines. Murine models support participation of interleukin-4 (IL-4) and the IL-4 receptor in asthma. Selective neutralization of IL-13, a cytokine related to IL-4 that also binds to the alpha chain of the IL-4 receptor, ameli...
Topics
- Adoptive Transfer
- Allergens
- Animals
- Asthma
- Bronchial Hyperreactivity
- Bronchoalveolar Lavage Fluid
- Chromosomes, Human, Pair 5
- Goblet Cells
- Humans
- Immunoglobulin Fc Fragments
- Interleukin-13
- Interleukin-13 Receptor alpha1 Subunit
- Interleukin-4
- Mice