Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL-13 is a susceptibility factor for Leishmania major infection.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2000

Matthews D J, Emson C L, McKenzie G J, Jolin H E, Blackwell J M, McKenzie A N

Abstract excerpt

Leishmania major infection is useful as an experimental model to define factors responsible for the development and maintenance of Th cell immune responses. Studies using inbred mouse strains have identified that the Th1 response characteristic of C57BL/6 mice results in healing, whereas BALB/c mice fail to control the infection due to the generation of an inappropriate Th2 response. We now demonstrate that IL-13...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Tolerance
Share to Immunity, Innate
Share to Interleukin-13

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-4

Share to Leishmania major

Share to Leishmaniasis, Cutaneous

Share to Mice, Inbred BALB C

Share to Th1 Cells

Source

Identifiers

PMID: 10640762
DOI: 10.4049/jimmunol.164.3.1458

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL-13 is a susceptibility factor for Leishmania major infection.PMID 10640762Read ↗

An essential role for IL-13 in maintaining a non-healing response following Leishmania mexicana infectionSemantic proximity Read ↗

IL-4-independent inhibition of IL-12 responsiveness during Leishmania amazonensis infection.Semantic proximity Read ↗

The role of IL-4, IL-13 and IL-4Ralpha in the development of protective and pathological responses to Trichinella spiralis.Semantic proximity Read ↗

Control of New World cutaneous leishmaniasis is IL-12 independent but STAT4 dependentSemantic proximity Read ↗

IL-4- and IL-4 Receptor-Deficient BALB/c Mice Reveal Differences in Susceptibility to Leishmania major Parasite SubstrainsSemantic proximity Read ↗

The Regulation of Immunity to Leishmania MajorSemantic proximity Read ↗

IL-4-deficient Balb/c mice resist infection with Leishmania major.Semantic proximity Read ↗

Infection of C57BL/10ScCr and C57BL/10ScNCr mice withLeishmania majorreveals a role for Toll-like receptor 4 in the control of parasite replicationSemantic proximity Read ↗

Impaired Th1 responses in mice deficient in Epstein‐Barr virus‐induced gene 3 and challenged with physiological doses of <i>Leishmania major</i>Semantic proximity Read ↗

Genetic background influences immune responses and disease outcome of cutaneous L. mexicana infection in mice.Semantic proximity Read ↗

Polarized helper-T-cell responses against Leishmania major in the absence of B cells.Semantic proximity Read ↗

The murine model of infection with Leishmania major and its importance for the deciphering of mechanisms underlying differences in Th cell differentiation in mice from different genetic backgrounds.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.