Article
Association studies in candidate genes: strategies to select SNPs to be tested.
Human heredity - 1 Jan 2003
Cousin E, Genin E, Mace S, Ricard S, Chansac C, del Zompo M, Deleuze J F
Abstract excerpt
OBJECTIVE: When numerous single nucleotide polymorphisms (SNPs) have been identified in a candidate gene, a relevant and still unanswered question is to determine how many and which of these SNPs should be optimally tested to detect an association with the disease. Testing them all is expensive and often unnecessary. Alleles at different SNPs may be associated in the population because of the existence of linkage...
Topics
- Algorithms
- Apolipoproteins E
- Chromosome Mapping
- Computational Biology
- Gene Frequency
- Genetic Markers
- Haplotypes
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Mucin-5B