SNP subset selection for genetic association studies.

doi:10.1046/j.1529-8817.2003.00055.x

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Article

SNP subset selection for genetic association studies.

Annals of human genetics - 1 Nov 2003

Byng M C, Whittaker J C, Cuthbert A P, Mathew C G, Lewis C M

Abstract excerpt

Association studies for disease susceptibility genes rely on the high density of SNPs within candidate genes. However, the linkage disequilibrium between SNPs imply that not all SNPs identified in the candidate region need be genotyped. Here we develop several approaches to SNP subset selection,...

Topics

Cluster Analysis
Decision Theory
Gene Frequency
Genotype
Haplotypes
Humans
Linkage Disequilibrium
Matrix Metalloproteinase 2
Models, Genetic
Polymorphism, Single Nucleotide
Regression Analysis
Research Design
Sample Size

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