Article
The AcB/BcA recombinant congenic strains of mice: strategies for phenotype dissection, mapping and cloning of quantitative trait genes.
Novartis Foundation symposium - 1 Jan 2007
Fortin Anny, Diez Eduardo, Henderson Janet E, Mogil Jeffrey S, Gros Philippe, Skamene Emil
Abstract excerpt
The AcB/BcA gene discovery platform consists of a series of 36 recombinant congenic strains (RCS) produced from the second backcross generation of the progenitor mouse strains A/J and C57BL/6J. Each individual inbred RCS carries 12.5% of the donor genome in 87.5% of the background genome. As the two parental strains are known to vary in the expression of resistance and susceptibility to a considerable number of...
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