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Article

The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility.

Journal of lipid research - 1 Jun 2004

Selva David M, Hirsch-Reinshagen Veronica, Burgess Braydon, Zhou Steven, Chan Jeniffer, McIsaac Sean, Hayden Michael R, Hammond Geoffrey L, Vogl A Wayne, Wellington Cheryl L

Abstract excerpt

The liver X receptor/retinoid X receptor (LXR/RXR)-regulated gene ABCA1 effluxes cellular cholesterol and phospholipid to apolipoprotein A1 (apoA1), which is the rate-limiting step in high-density lipoprotein synthesis. The RXR pathway plays a critical role in testicular lipid trafficking, and RX...

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Source

Identifiers

PMID: 15026428
DOI: 10.1194/jlr.M400007-JLR200

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15026428-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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