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Article

The liver X receptor-{beta} is essential for maintaining cholesterol homeostasis in the testis.

Endocrinology - 1 Jun 2005

Robertson Kirsten M, Schuster Gertrud U, Steffensen Knut R, Hovatta Outi, Meaney Steve, Hultenby Kjell, Johansson Lisen C, Svechnikov Konstantin, Söder Olle, Gustafsson Jan-Ake

Abstract excerpt

The liver X receptor (LXR)alpha and -beta has been found to play a central role in maintaining cellular cholesterol homeostasis. In this study we comprehensively investigated the effect of deleting LXRalpha and -beta on testicular morphology and function. In the absence of LXRbeta, excessive cholesterol accumulated in the Sertoli cells from 2.5 months, resulting in severe cellular disruption and dysregulation of...

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Source

Identifiers

PMID: 15761042
DOI: 10.1210/en.2004-1413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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