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Dietary xenosterols lead to infertility and loss of abdominal adipose tissue in sterolin-deficient mice

24 Nov 2012

Abstract excerpt

The investigation of the human disease sitosterolemia (MIM 210250) has shed light not only on the pathways by which dietary sterols may traffic but also on how the mammalian body rids itself of cholesterol and defends against xenosterols. Two genes, ABCG5 and ABCG8, located at the sitosterolemia locus, each encodes a membrane-bound ABC half-transporter and constitutes a functional unit whose activity has now been...

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PMID: 23180829
DOI: 10.1194/jlr.m031476

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