Article
Crohn disease: frequency and nature of CARD15 mutations in Ashkenazi and Sephardi/Oriental Jewish families.
American journal of human genetics - 1 Apr 2004
Tukel Turgut, Shalata Adel, Present Daniel, Rachmilewitz Daniel, Mayer Lloyd, Grant Deniera, Risch Neil, Desnick Robert J
Abstract excerpt
Crohn disease (CD), an inflammatory bowel disease, is a multifactorial trait with the highest frequency in Ashkenazi Jewish (AJ) individuals of Central European origin. Recently, three common predisposing CARD15 mutations (R702W, G908R, and 1007fs) and a polymorphism (P268S) were identified. To determine whether CARD15 mutations account for the higher prevalence of CD in AJ individuals, the haplotypes and allele...
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