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Article

Variation at NOD2/CARD15 in familial and sporadic cases of Crohn's disease in the Ashkenazi Jewish population.

The American journal of gastroenterology - 1 Dec 2002

Zhou Zhifeng, Lin Xing-Yu, Akolkar Pradip N, Gulwani-Akolkar Beena, Levine Jeremiah, Katz Seymour, Silver Jack

Abstract excerpt

OBJECTIVE: Recent reports indicate that allelic variants in NOD2/CARD15 are associated with Crohn's disease (CD) susceptibility, and that homozygosity or compound heterozygosity at this locus for any of three recently defined sequence variants confers a greatly increased risk of CD. These sequence changes include two missense mutations, R702W and G908R, and a frameshift insertion, 1007insC. The aim of this study...

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Source

Identifiers

PMID: 12492195
DOI: 10.1111/j.1572-0241.2002.07105.x

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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