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Article

Silencing of Hepatitis A Virus Infection by Small Interfering RNAs

12 May 2006

Abstract excerpt

Infection by hepatitis A virus (HAV) can cause acute hepatitis and, rarely, fulminant liver failure, in particular in patients chronically infected with hepatitis C virus. Based on our previous observation that small interfering RNAs (siRNAs) can silence translation and replication of the firefly luciferase-encoding HAV replicon, we now exploited this technology to demonstrate the effect of siRNAs on viral...

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PMID: 16699041
DOI: 10.1128/jvi.01773-05

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