Article
First large, multicenter, open-label study utilizing HLA-B*5701 screening for abacavir hypersensitivity in North America.
AIDS (London, England) - 20 Aug 2008
Young Benjamin, Squires Kathleen, Patel Parul, Dejesus Edwin, Bellos Nicholaos, Berger Daniel, Sutherland-Phillips Denise H, Liao Qiming, Shaefer Mark, Wannamaker Paul
Abstract excerpt
A hypersensitivity reaction is associated with abacavir in approximately 2-8% of exposed patients. The frequency of the HLA-B*5701 allele varies across racial groups and significantly correlates with risk of hypersensitivity. Studies in Europe and Western Australia demonstrated that prospective screening can significantly reduce the rate of hypersensitivity by avoiding the use of abacavir in patients carrying the...
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