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Article

HLA-B*5701 screening for hypersensitivity to abacavir.

The New England journal of medicine - 7 Feb 2008

Mallal Simon, Phillips Elizabeth, Carosi Giampiero, Molina Jean-Michel, Workman Cassy, Tomazic Janez, Jägel-Guedes Eva, Rugina Sorin, Kozyrev Oleg, Cid Juan Flores, Hay Phillip, Nolan David, Hughes Sara, Hughes Arlene, Ryan Susanna, Fitch Nicholas, Thorborn Daren, Benbow Alastair

Abstract excerpt

BACKGROUND: Hypersensitivity reaction to abacavir is strongly associated with the presence of the HLA-B*5701 allele. This study was designed to establish the effectiveness of prospective HLA-B*5701 screening to prevent the hypersensitivity reaction to abacavir. METHODS: This double-blind, prospective, randomized study involved 1956 patients from 19 countries, who were infected with human immunodeficiency virus...

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Identifiers

PMID: 18256392
DOI: 10.1056/NEJMoa0706135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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