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Article

Distinct roles for ATP binding and hydrolysis at individual subunits of an archaeal clamp loader.

The EMBO journal - 24 Mar 2004

Seybert Anja, Wigley Dale B

Abstract excerpt

Circular clamps are utilised by replicative polymerases to enhance processivity. The topological problem of loading a toroidal clamp onto DNA is overcome by ATP-dependent clamp loader complexes. Different organisms use related protein machines to load clamps, but the mechanisms by which they utilise ATP are surprisingly different. Using mutant clamp loaders that are deficient in either ATP binding or hydrolysis...

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Identifiers

PMID: 15014449
DOI: 10.1038/sj.emboj.7600130
PMCID: PMC381406

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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