Article
The CTPase activity of ParB determines the size and dynamics of prokaryotic DNA partition complexes.
Molecular cell - 7 Oct 2021
Osorio-Valeriano Manuel, Altegoer Florian, Das Chandan K, Steinchen Wieland, Panis Gaël, Connolley Lara, Giacomelli Giacomo, Feddersen Helge, Corrales-Guerrero Laura, Giammarinaro Pietro I, Hanßmann Juri, Bramkamp Marc, Viollier Patrick H, Murray Seán, Schäfer Lars V, Bange Gert, Thanbichler Martin
Abstract excerpt
ParB-like CTPases mediate the segregation of bacterial chromosomes and low-copy number plasmids. They act as DNA-sliding clamps that are loaded at parS motifs in the centromere of target DNA molecules and spread laterally to form large nucleoprotein complexes serving as docking points for the DNA segregation machinery. Here, we solve crystal structures of ParB in the pre- and post-hydrolysis state and illuminate...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.