Article
Molecular analyses of a three-subunit euryarchaeal clamp loader complex from Methanosarcina acetivorans.
Journal of bacteriology - 1 Nov 2009
Chen Yi-Hsing, Lin Yuyen, Yoshinaga Aya, Chhotani Benazir, Lorenzini Jenna L, Crofts Alexander A, Mei Shou, Mackie Roderick I, Ishino Yoshizumi, Cann Isaac K O
Abstract excerpt
Chromosomal DNA replication is dependent on processive DNA synthesis. Across the three domains of life and in certain viruses, a toroidal sliding clamp confers processivity to replicative DNA polymerases by encircling the DNA and engaging the polymerase in protein/protein interactions. Sliding cl...
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