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Article

A central swivel point in the RFC clamp loader controls PCNA opening and loading on DNA.

Journal of molecular biology - 17 Feb 2012

Sakato Miho, O'Donnell Mike, Hingorani Manju M

Abstract excerpt

Replication factor C (RFC) is a five-subunit complex that loads proliferating cell nuclear antigen (PCNA) clamps onto primer-template DNA (ptDNA) during replication. RFC subunits belong to the AAA(+) superfamily, and their ATPase activity drives interactions between the clamp loader, the clamp, and the ptDNA, leading to topologically linked PCNA·ptDNA. We report the kinetics of transient events in Saccharomyces...

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Source

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Identifiers

PMID: 22197374
DOI: 10.1016/j.jmb.2011.12.017
PMCID: PMC3269524

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A central swivel point in the RFC clamp loader controls PCNA opening and loading on DNA.PMID 22197374Read ↗

Kinetic analysis of PCNA clamp binding and release in the clamp loading reaction catalyzed by Saccharomyces cerevisiae replication factor C.Semantic proximity Read ↗

Mechanism of proliferating cell nuclear antigen clamp opening by replication factor C.Semantic proximity Read ↗

The structure of a ring-opened proliferating cell nuclear antigen-replication factor C complex revealed by fluorescence energy transfer.Semantic proximity Read ↗

Structure of the human clamp loader bound to the sliding clamp: a further twist on AAA+ mechanismSemantic proximity Read ↗

Recruitment of DNA repair synthesis machinery to sites of DNA damage/repair in living human cellsSemantic proximity Read ↗

Destabilized PCNA trimers suppress defective Rfc1 proteins in vivo and in vitro.Semantic proximity Read ↗

ATPase switches controlling DNA replication initiation.Semantic proximity Read ↗

Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFCSemantic proximity Read ↗

CAF-1 in Replication and Repair: A Critical Genetic Mediator of Synthesis-Coupled Nucleosome AssemblySemantic proximity Read ↗

'PIPs' in DNA polymerase: PCNA interaction affairs.Semantic proximity Read ↗

Biochemical Characterization of DNA Damage Checkpoint Complexes: Clamp Loader and Clamp Complexes with Specificity for 5′ Recessed DNASemantic proximity Read ↗

The Escherichia coli clamp loader can actively pry open the β-sliding clamp.Semantic proximity Read ↗

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