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Article

Ordered ATP hydrolysis in the gamma complex clamp loader AAA+ machine.

The Journal of biological chemistry - 18 Apr 2003

Johnson Aaron, O'Donnell Mike

Abstract excerpt

The gamma complex couples ATP hydrolysis to the loading of beta sliding clamps onto DNA for processive replication. The gamma complex structure shows that the clamp loader subunits are arranged as a circular heteropentamer. The three gamma motor subunits bind ATP, the delta wrench opens the beta ring, and the delta' stator modulates the delta-beta interaction. Neither delta nor delta' bind ATP. This report...

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Identifiers

PMID: 12582167
DOI: 10.1074/jbc.M212708200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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