Article
The Escherichia coli clamp loader can actively pry open the β-sliding clamp.
The Journal of biological chemistry - 9 Dec 2011
Paschall Christopher O, Thompson Jennifer A, Marzahn Melissa R, Chiraniya Ankita, Hayner Jaclyn N, O'Donnell Mike, Robbins Arthur H, McKenna Robert, Bloom Linda B
Abstract excerpt
Clamp loaders load ring-shaped sliding clamps onto DNA. Once loaded onto DNA, sliding clamps bind to DNA polymerases to increase the processivity of DNA synthesis. To load clamps onto DNA, an open clamp loader-clamp complex must form. An unresolved question is whether clamp loaders capture clamps that have transiently opened or whether clamp loaders bind closed clamps and actively open clamps. A simple...
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