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Article

Deletion of the kinase domain in death-associated protein kinase attenuates renal tubular cell apoptosis in chronic obstructive uropathy.

International journal of molecular medicine - 1 Apr 2004

Yukawa Kazunori, Hoshino Katsuaki, Kishino Masanori, Mune Masatoshi, Shirasawa Nobuyuki, Kimura Akihiko, Tsubota Yuji, Owada-Makabe Kyoko, Tanaka Tetsuji, Ichinose Masakazu, Maeda Masanobu, Takeda Kiyoshi, Akira Shizuo

Abstract excerpt

Death-associated protein kinase (DAPK) is a Ca2+/calmodulin-dependent serine/threonine kinase that has been implicated as a positive mediator of apoptosis. However, little is known about the involvement of DAPK in the apoptosis associated with several pathological states, except for cancer. Here, DAPK-mutant mice were used in order to examine the role of DAPK in renal cell apoptosis in chronic obstructive...

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PMID: 15010850

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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