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Article

The kinase domain of death-associated protein kinase is inhibitory for tubulointerstitial fibrosis in chronic obstructive nephropathy.

International journal of molecular medicine - 1 Jan 2005

Yukawa Kazunori, Kishino Masanori, Hoshino Katsuaki, Shirasawa Nobuyuki, Kimura Akihiko, Tsubota Yuji, Owada-Makabe Kyoko, Bai Tao, Tanaka Tetsuji, Ueyama Takashi, Ichinose Masakazu, Takeda Kiyoshi, Akira Shizuo, Maeda Masanobu

Abstract excerpt

Death-associated protein kinase (DAPK) is a Ca2+/calmodulin-dependent serine/threonine kinase that is thought to mediate apoptosis. We have shown that the kinase domain of DAPK is crucial for the induction of renal tubular cell apoptosis in chronic obstructive uropathy (COU) created by unilateral ureteral ligation. DAPK-mutant mice, generated by deletion of 74 amino acids from the catalytic kinase domain, were...

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PMID: 15583830

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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