Article
Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells.
Molecular cell - 1 Nov 2000
Boletta A, Qian F, Onuchic L F, Bhunia A K, Phakdeekitcharoen B, Hanaoka K, Guggino W, Monaco L, Germino G G
Abstract excerpt
The major form of autosomal dominant polycystic kidney disease (ADPKD) results from mutation of a gene (PKD1) of unknown function that is essential for the later stages of renal tubular differentiation. In this report, we describe a novel cell culture system for studying how PKD1 regulates this process. We show that expression of human PKD1 in MDCK cells slows their growth and protects them from programmed cell...
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