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Article

Pkd1 haploinsufficiency increases renal damage and induces microcyst formation following ischemia/reperfusion.

Journal of the American Society of Nephrology : JASN - 1 Nov 2009

Bastos Ana P, Piontek Klaus, Silva Ana M, Martini Dino, Menezes Luis F, Fonseca Jonathan M, Fonseca Ivone I, Germino Gregory G, Onuchic Luiz F

Abstract excerpt

Mutations in PKD1 cause the majority of cases of autosomal dominant polycystic kidney disease (ADPKD). Because polycystin 1 modulates cell proliferation, cell differentiation, and apoptosis, its lower biologic activity observed in ADPKD might influence the degree of injury after renal ischemia/reperfusion. We induced renal ischemia/reperfusion in 10- to 12-wk-old male noncystic Pkd1(+/-) and wild-type mice....

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Share to PKD1 gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney Diseases, Cystic

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Source

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Identifiers

PMID: 19833899
DOI: 10.1681/ASN.2008040435
PMCID: PMC2799174

Genes

PKD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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