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Article

Deletion of the kinase domain in death-associated protein kinase attenuates tubular cell apoptosis in renal ischemia-reperfusion injury.

Journal of the American Society of Nephrology : JASN - 1 Jul 2004

Kishino Masanori, Yukawa Kazunori, Hoshino Katsuaki, Kimura Akihiko, Shirasawa Nobuyuki, Otani Haruhisa, Tanaka Tetsuji, Owada-Makabe Kyoko, Tsubota Yuji, Maeda Masanobu, Ichinose Masakazu, Takeda Kiyoshi, Akira Shizuo, Mune Masatoshi

Abstract excerpt

Death-associated protein kinase (DAPK) is a calcium/calmodulin-dependent serine/threonine kinase localized to renal tubular epithelial cells. To elucidate the contribution of DAPK activity to apoptosis in renal ischemia-reperfusion (IR) injury, wild-type (WT) mice and DAPK-mutant mice, which express a DAPK deletion mutant that lacks a portion of the kinase domain, were subjected to renal pedicle clamping and...

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PMID: 15213270
DOI: 10.1097/01.asn.0000131527.59781.f2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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