Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cystogenesis in ARPKD results from increased apoptosis in collecting duct epithelial cells of Pkhd1 mutant kidneys.

Experimental cell research - 15 Jan 2011

Hu Bo, He Xiusheng, Li Ao, Qiu Qingchao, Li Cunxi, Liang Dan, Zhao Ping, Ma Jie, Coffey Robert J, Zhan Qimin, Wu Guanqing

Abstract excerpt

Mutations in the PKHD1 gene result in autosomal recessive polycystic kidney disease (ARPKD) in humans. To determine the molecular mechanism of the cystogenesis in ARPKD, we recently generated a mouse model for ARPKD that carries a targeted mutation in the mouse orthologue of human PKHD1. The homo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspase 3
Share to Caspase 9
Share to Cell Line, Transformed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, cdc

Share to Kidney Tubules, Collecting

Share to Mice, Congenic

Share to Polycystic Kidney, Autosomal Recessive

Source

Identifiers

PMID: 20875407
DOI: 10.1016/j.yexcr.2010.09.012

Genes

PKHD1
PCNA
PDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20875407-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cystogenesis in ARPKD results from increased apoptosis in collecting duct epithelial cells of Pkhd1 mutant kidneys.PMID 20875407Read ↗

Molecular and cellular pathophysiology of autosomal recessive polycystic kidney disease (ARPKD).Semantic proximity Read ↗

Role of apoptosis in the development of autosomal dominant polycystic kidney disease (ADPKD).Semantic proximity Read ↗

Kidney cysts, pancreatic cysts, and biliary disease in a mouse model of autosomal recessive polycystic kidney disease.Semantic proximity Read ↗

Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells.Semantic proximity Read ↗

c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney diseaseSemantic proximity Read ↗

Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.Semantic proximity Read ↗

Autosomal recessive polycystic kidney disease (ARPKD): new insights from the identification of the ARPKD gene, PKHD1.Semantic proximity Read ↗

c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease.Semantic proximity Read ↗

NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology.Semantic proximity Read ↗

Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway.Semantic proximity Read ↗

<i>Ankhd1</i> enhances polycystic kidney disease development via promoting proliferation and fibrosisSemantic proximity Read ↗

Cyclin-Dependent Kinase 1 Activity Is a Driver of Cyst Growth in Polycystic Kidney Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.