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Article

Acceleration of polycystic kidney disease progression in cpk mice carrying a deletion in the homeodomain protein Cux1.

American journal of physiology. Renal physiology - 1 Dec 2008

Alcalay Neal I, Sharma Madhulika, Vassmer Dianne, Chapman Brandon, Paul Binu, Zhou Jing, Brantley Jennifer G, Wallace Darren P, Maser Robin L, Vanden Heuvel Gregory B

Abstract excerpt

Polycystic kidney diseases (PKD) are inherited as autosomal dominant (ADPKD) or autosomal recessive (ARPKD) traits and are characterized by progressive enlargement of renal cysts. Aberrant cell proliferation is a key feature in the progression of PKD. Cux1 is a homeobox gene that is related to Drosophila cut and is the murine homolog of human CDP (CCAAT Displacement Protein). Cux1 represses the cyclin kinase...

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Identifiers

PMID: 18829740
DOI: 10.1152/ajprenal.90420.2008
PMCID: PMC2604819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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