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Article

DAP-kinase participates in TNF-alpha- and Fas-induced apoptosis and its function requires the death domain.

The Journal of cell biology - 12 Jul 1999

Cohen O, Inbal B, Kissil J L, Raveh T, Berissi H, Spivak-Kroizaman T, Feinstein E, Kimchi A

Abstract excerpt

Death-associated protein (DAP)-kinase is a calcium/calmodulin regulated serine/threonine kinase that carries ankyrin repeats, a death domain, and is localized to the cytoskeleton. Here, we report that this kinase is involved in tumor necrosis factor (TNF)-alpha and Fas-induced apoptosis. Expression of DAP-kinase antisense RNA protected cells from killing by anti-Fas/APO-1 agonistic antibodies. Deletion of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10402466
DOI: 10.1083/jcb.146.1.141
PMCID: PMC2199731

Genes

DAP
TNF
FADD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DAP-kinase participates in TNF-alpha- and Fas-induced apoptosis and its function requires the death domain.PMID 10402466Read ↗

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