Article
Deletion of the kinase domain from death-associated protein kinase attenuates p53 expression in chronic obstructive uropathy.
International journal of molecular medicine - 1 Sept 2005
Yukawa Kazunori, Hoshino Katsuaki, Kishino Masanori, Tsubota Yuji, Owada-Makabe Kyoko, Maeda Masanobu, Bai Tao, Tanaka Tetsuji, Akira Shizuo
Abstract excerpt
Death-associated protein kinase (DAPK) is a Ca(2+)/calmodulin-dependent serine/threonine kinase that is thought to mediate apoptosis. We previously showed that the kinase domain of DAPK is crucial for the induction of renal tubular cell apoptosis in chronic obstructive uropathy (COU) caused by a...
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