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Article

Class-switched marginal zone B cells in spleen have relatively low numbers of somatic mutations.

Molecular immunology - 1 Mar 2011

Hendricks Jacobus, Visser Annie, Dammers Peter M, Burgerhof Johannes G M, Bos Nicolaas A, Kroese Frans G M

Abstract excerpt

The vast majority of rodent splenic marginal zone (MZ)-B cells are naive IgM(+) cells. A small fraction of these MZ-B cells carry mutated V-genes, and represent IgM(+) memory MZ-B cells. Here we reveal further heterogeneity of B cells with a MZ-B cell phenotype, by providing evidence for the existence of class-switched memory MZ-B cells in the rat. In essence, we observed IGHV5 encoded Cγ transcripts, among...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21256598
DOI: 10.1016/j.molimm.2010.12.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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